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KMID : 0191120100250030481
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Journal of Korean Medical Science
2010 Volume.25 No. 3 p.481 ~ p.484
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Primary T-cell Lymphoma of the Thyroid Associated with Hashimoto’s Thyroiditis, Histologically Mimicking MALT-Lymphoma
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Kim Na-Rai
Ko Young-Hyeh
Lee Young-Don
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Abstract
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Most of thyroid lymphomas are B-lineage, and T-cell lymphomas are rare. Here, we report a case of primary thyroid T-cell lymphoma associated with Hashimoto’s thyroiditis. A 48-yr-old woman presented with incidentally found neck mass. Histologically, the resected right lobe of the thyroid was replaced by monomorphic small atypical lymphoid cells with lymphoepithelial lesion-like change, most of which were immunoreactive for CD3, CD8, βF-1, and TIA-1. Peripheral T-cell lymphoma, unspecified, was finally diagnosed after molecular study for TCR-γ gene rearrangement. This is the second case of cytotoxic T-cell lymphoma reported in the thyroid gland so far. Unique association between thyroid follicles and neoplastic lymphocytes may be characteristic feature of this type of T-cell lymphoma.
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KEYWORD
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Lymphoma, T-Cell’Thyroid Gland, T-Lymphocytes, Cytotoxic, Lymphoma, B-Cell, Marginal Zone
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